Lipid-induced endoplasmic reticulum stress in X-linked adrenoleukodystrophy
نویسندگان
چکیده
منابع مشابه
naltrexone attenuates endoplasmic reticulum stress induced hepatic injury in mice
endoplasmic reticulum (er) stress provides abnormalities in insulin action, inflammatory responses, lipoprotein b100 degradation and hepatic lipogenesis. excess accumulation of triglyceride in hepatocytes may also lead to disorders such as non-alcoholic fatty liver disease (nafld) and nonalcoholic steatohepatitis (nash). opioid peptides are involved in triglyceride and cholesterol dysregulat...
متن کاملEndoplasmic Reticulum Stress and Lipid Metabolism
1Department of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA 2Hunter Holmes McGuire VA Medical Center, Richmond, VA 23298, USA 3Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA 4Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, MI...
متن کاملThe X-linked adrenoleukodystrophy (X-ALD) and oxidative stress.
Most of the studies indicate that there is as yet no complete cure for X-ALD. However, methods of the treatment seem to slow rather than treat the disease. One method is the use of Lorenzo's oil in conjunction with a low fat diet, which may help in cerebral X-ALD. X-ALD is in very close resemblance to another neurodegenerative disease, amyotrophic lateral sclerosis (ALS). One of the believed pa...
متن کاملX-Linked Adrenoleukodystrophy: Focus on Lipid and Steroid Hormone Metabolism
X-linked adrenoleukodystrophy (X-ALD) is an inherited demyelinating disorder characterized by the accumulation of saturated very long chain fatty acids (VLCFA) in plasma and tissues. Adrenocortical insufficiency and symptoms of alopecia and hypogonadism indicate a role of steroid hormones, particularly androgens in this disease. Fibroblasts from X-ALD patients exhibit abnormalities in the funct...
متن کاملInflammation in X - linked Adrenoleukodystrophy
Project Description: Cells compute by processing external stimuli according to their internal state, abiding to rules that remain poorly understood (Rubens et al., 2016). Cell fate decisions are the key for constructing a multicellular organism. Errors, bias or aberrant delays in making such decisions can lead to neoplasia or in extreme cases, tumorigenesis. Our key question is how cells make d...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
سال: 2017
ISSN: 0925-4439
DOI: 10.1016/j.bbadis.2017.06.003